some “Sterilisation” HINTS . . . To ensure max Sterility - use sterile processes and methodology in ALL handling
- Your responsibilty ! . . . strictly to TGA requirements - and may even require YOUR TGA certification
for example for final Vial filling - Use a Sterile Syringe Filter 0.22um Pore is regarded as providing a high degree of sterility
0.45um is limited in this respect
For “oils” or non polar material use
- PVDF ”SFPVDF025022SG with a 1.0um Glass Fibre pre Filter
For water solutions . . .
- Nylon SFNY025022SG
These 0.22um filter can be very slow ie easily blocked
- in which case use 0.45um version then followed by a the 0,.22um for more effective sterilisation
0.45um only achieves a partial sterilisation ( some
The 1um GF prefilter helps remove difficult suspended particulate material preserves/prolongs the life of the main filter
Choice of filter materials is left to users discretion
- PES ( polyethersulfone) a newer media is reported to produce faster and more effective filtration for many water based applications versus Nylon, cellulose acetate etc
Use of full vacuum filtration - flask / funnels vacuum Pump ( motorised ) is recommended for “bulk Solutions”
and “initial” cleanup
Filtration, Vac Pmps
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